A series of biologically active cinchophen analogues, 2-(1-benzofuran-2-yl) quinoline-4-carboxylic acid and 2-(5-bromo-1-benzofuran-2-yl) quinoline-4-carboxylic acid have been synthesized using Pfitzinger method. The structures were established by IR, 1HNMR and mass spectral data. Antibacterial results revealed that compounds 3a, 3b, 3e, and 3f possess good activity against Pantoea dispersa. Whereas, compounds 3a, 3c, 3g and 3h have showed good activity against Ochrobacterium species, Entercoccus species and Staphylococcus aureus at 100 μg/ml concentration. The compound 3g showed significant analgesic and anti-inflammatory activity at a concentration of 100 mg/kg body weight, when compared with other compounds.
Loading....